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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0432 | Diclofenac diethylamine | Apoptosis , COX | |
Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID). | |||
T2667 | PIK-75 | Apoptosis , DNA-PK , PI3K | |
PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM). | |||
T0196 | Diclofenac | Diclofenacum,Voltaren | Apoptosis , COX |
Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of a... | |||
T1566 | Aripiprazole | OPC-14597 | 5-HT Receptor |
Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a... | |||
T6470 | Diclofenac Potassium | CGP-45840B,Cataflam,Voltfast | Apoptosis , Others , COX |
Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. | |||
T1555 | Diclofenac sodium | GP 45840 | Apoptosis , COX |
Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. | |||
T23386 | SR 142948 | Neurotensin Receptor | |
SR 142948 is a neurotensin (NT) receptor antagonist. | |||
T2287 | PIK-75 hydrochloride | PIK-75 HCl,PIK-75 | Apoptosis , DNA-PK , PI3K |
PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays. | |||
TQ0227 | Etrasimod | APD334 | S1P Receptor , LPL Receptor |
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells). | |||
T4626L | TC-O 9311 | TCO-9311,TC-O9311,TCO 9311,TC-O 9311,TCO9311,TC-O-9311 | GPR |
TC-O 9311 (TCO-9311) is an effective agonist of GPR139 (EC50 = 39 nM in CHO-K1 cells expressing human GPR139). | |||
T19122 | 3-Methylvaleric Acid | Others , Endogenous Metabolite | |
3-Methylvaleric Acid is an edible grade flavor present in tobacco.3-Methylvaleric Acid enhances intracellular cAMP accumulation and CRE-luciferase activity in CHO-K1 cells and HEK293 cells. | |||
T8449 | TC-I2000 | TRP/TRPV Channel | |
TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM. | |||
T9650 | AZ12672857 | Src , Ephrin Receptor | |
AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphorylation of EphB4 in transfected CHO-K1 cells with IC50 of 9 n... | |||
T12670 | (Rac)-MGV354 | MGV354 | Others |
(Rac)-MGV354 (MGV354) is the racemate of MGV354. MGV354 is a soluble activator of guanylate cyclase (sGC)(EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively). | |||
T6329 | 3-Aminobenzamide | 3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001 | PARP |
3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion. | |||
T12930 | SKF89976A hydrochloride | d,l-SKF89976A hydrochloride | GABA Receptor |
SKF89976A hydrochloride (d,l-SKF89976A hydrochloride) is a selective inhibitor GABA transporter such as GAT-1 (IC50s = 0.28 μM), GAT-2 (IC50s = 137.34 μM) and GAT-3(IC50s = 202.8 μM) in CHO cells. | |||
T14944 | CGS 15943 | PI3K , Adenosine Receptor | |
CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM , respectively. | |||
TP1199L | Urotensin I acetate (83930-33-0 Free base) | CRFR | |
Urotensin I acetate, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hC... | |||
T22126 | Org 25543 hydrochloride | GlyT | |
Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptak... | |||
T5081 | Adenine monohydrochloride hemihydrate | Adenine hydrochloride hydrate,6-Aminopurine hydrochloride hydrate | Endogenous Metabolite , Adenosine Receptor |
Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor a... |